three-Methoxyphencyclidine (3meopcp) is a dissociative hallucinogen of the arylcyclohexylamine class related to phencyclidine (PCP) which has been bought online as a designer drug. It acts especially as an NMDA receptor antagonist, even though it has also been located to interact with the sigma σ1 receptor and the serotonin transporter. The drug does not own any opioid pastime nor does it act as a dopamine reuptake inhibitor.
3meopcp has a Ki of 20 nM for the dizocilpine (MK-801) web page of the NMDA receptor, 216 nM for the serotonin transporter (SERT), and forty two nM for the sigma σ1 receptor. It does not bind to the norepinephrine or dopamine transporter nor to the sigma σ2 receptor (Ki >10,000 nM). primarily based on its structural similarity to 3-hydroxy-PCP (three-HO-PCP), which uniquely among arylcyclohexylamines has high affinity for the μ-opioid receptor in addition to the NMDA receptor, it become first of all anticipated that 3meopcp would have opioid activity. however, radioligand binding assays with human proteins have shown that, opposite to common belief, the drug also does now not interact with the μ-, δ-, or κ-opioid receptors at concentrations of up to 10,000 nM. As such, the notion that 3meopcp has opioid activity has been described as a fable.
three-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the very best affinity of the three isomeric anisyl-substitutions of PCP, accompanied by means of 2-MeO-PCP and 4-MeO-PCP.
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